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The final proposed mechanism of RBC vasodilation within the existence of nitrite is definitely the reduction of nitrite to NO by Hb. Brooks first examined the nitrite Hb conversation in 1937 and this operate was later on extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to sort metHb and NO (Brooks, 1